Journal Archives - Recent Issue
Professor Jayant Radhakrishnan, MD
Emeritus Professor of Surgery and Urology,
University of Illinois,
Chicago, Illinois, USA
Dr. Jayant Radhakrishnan, MBBS, MS (Surgery), Diplomate American Board of Surgery, FACS, FAAP is an Emeritus Professor of Surgery and Urology at the University of Illinois, Chicago where he was the Chief of pediatric Surgery and Pediatric Urology at the time of his retirement.
He was listed amongst the Best Doctors in Chicago, on 6 occasions. The Department of Surgery, of the University of Illinois awarded him the Distinguished Service Award (1998) and the Olga Jonasson Teaching Award (1999). In addition he has received four teaching awards from Pediatric residents, the Leelavati Upadhyaya medal of the Indian Society of Paediatric Urology (2000), the Sushruta award from the Association of Indians in America (2002), the Pediatric Urology Foundation medal of the Asian Society of Pediatric Urology (2003), and the RK Gandhi award of the Indian Association of Pediatric Surgeons (2007).
In 2013 the University of Illinois honored him by establishing the endowed Jayant Radhakrishnan Professorship in Pediatric Surgery.
Jayant is the founding editor of Progress in Paediatric Urology and a regular visiting faculty to meetings of the Indian & Asian Societies for Paediatric Urology. He has contributed actively to almost all the volumes published so far and helped in identifying the best authors for particular topics.
He is known for his major reconstructive surgeries & epitomizes the surgeon with a 'lion's heart and an eagle's eye', not unlike his mentor, the legendary, W. Hardy Hendren, MD.
The editors & readership of Progress in Paediatric Urology is grateful to Professor Jayant Radhakrishnan, MD, for his whole hearted contribution, not only to Volume 15, but for his active involvement in the successful publication of this educational manual over the years.
In this article we discuss enzyme defects that cause lack of testosterone biosynthesis in males.
5α-reductase deficiency is a particularly dramatic form of XY Disorder of sex development. These individuals are severely feminized at birth but they masculinize and function as males at puberty. An understanding of the pathogenesis is essential to make rational management decisions.
The spectrum of Androgen Insensitivity Syndrome ranges from normal appearing females without a uterus at one end to normal appearing but infertile males at the other end of the spectrum. Such variation makes diagnosis and treatment complicated. In this article the authors place the various forms of the syndrome in context.
Congenital adrenal hyperplasia is the most common cause of 46,XX DSD. Early diagnosis and proper treatment are imperative since it is potentially life-threatening. In this article we discuss issues that are important in its diagnosis and management.
Patients with Mixed gonadal dysgenesis and Dysgenetic male pseudohermaphroditism have dysgenetic gonads, ambiguous external genitalia and a well-developed Mullerian ductal system. In addition to the need for appropriate sex assignment and genital reconstruction the abnormal gonads have to be dealt with because they carry a high risk of developing tumors.
There is considerable confusion regarding the pathology, findings and the appropriate treatment of patients with ovo-testicular disorder of sex development. In this article we present principles that would help the clinician manage this rare but intriguing condition.
Persistent mullerian duct syndrome is a condition in which normally virilized males retain mullerian structures internally. It is a difficult condition to diagnose and its management is controversial.
Patients born with ambiguous genitalia and raised as females often require reconstructive surgery to improve the appearance or/and function of the genitalia. This article covers details of reconstructive surgery.
Cases of disorders of sexual development have an associated psychological and sexual taboo. There is always an associated delima in the management of these cases. Once a decision to rear a child as male is taken there comes the role of male genitoplasty. Male Genitoplasty in these cases is a compound procedure comprising of the constellation of procedures involving male urethroplasty as well as removal of associated mullerian structure and insertion of testicular prosthesis when required. Urethroplasty in these cases is challenging due to proximally located meatus and associated severe chordae. In this compilation we have tried to address upon the various aspects of male genitoplasty and also the difficulties and problems in their management.
The disorders of sexual development have attracted the attention of bioethicists, advocacy groups and policy makers due to the various moral concerns involved and the irreversible nature of most gender assignment procedures. To understand the multiple facets of the fascinating ethical dilemmas which arise in the minds of the clinicians, one must first understand the nature of this pathology. This article aims to encapsulate the evolution of the thought processes behind gender assignment and provide an overview of the ethical principles involved in intersexuality.
The essence of Scrotal Phalloplasty is, a) use of scrotal skin to reconstruct a temporary phallus, b) transpose the urethral meatus to create hypospadiac neomeatus, c) urethroplasty at a later stage & d) definitive penile reconstruction at puberty followed by insertion of penile prosthesis. In this chapter the author has describe a novel technique for phallic reconstruction, hitherto not described, yet simple to practice for this most difficult of urogenital anomalies.